Pick away...got a microscope and tweezers...? :wink:
You picked my favorite caliber and the most versitile round in the world. It is marginal for elephant, but will do the job. It is over gunned for deer, but doesn't damage as much meat as a 270...as a rule...
With 270 grain bullets it has the same trajectory as a 30-06 with 180's :idea:
It has a BIG push for recoil, but hits much softer than that hard jabbing 338... :shock: ...and I do like the 338 Win. The 375 gets nice and tame with 235's and isn't too bad with 270's. It does let you know that you just pulled the trigger, however...won't ever be a p-u-s-s-y-c-a-t...just isn't in it's blood. 8)
You also picked a great scope for the 375. The 2x7 Loopy is what is sitting on one of my three 375's. I have a 1.5x5 VXIII on another and a 3x9 VariXII on the third. I also have a Loopy 2.5x compact as the second scope for the one with the 3x9. It is a pre 64 Mdl 70, and I have Talley QD's on it; I use QD's on all heavy rifles and most of my other hunting rifles. The 3x9 is sighted in at 225 yards with my 270 gr. pet handload, and the 2.5x is sighted in for Woodleigh 350 gr solids and softs at 100 yards for closer and more serious work.
I am a firm believer in the opinion that a 375 without good open sights is worth about as little as yesterday's newspaper.
As to what rifle...I like the Ruger RSM, but they are expensive and hard to find. Don't overlook the CZ550. I used one on cape buffalo in 2000 in Tanzania in 416 Rigby. It shot tighter groups than any other bigger bore I own, or have owned. They need to have the action glassed, however; they tend to crack stocks real fast if this isn't done. $25.00 worth of bedding kit and a few hours at the kitchen table will solve that problem.
I also like very much the 550's set trigger system and the rear sight one standing and two folding system. If you can get past the ugly European hog back stock design, you would like the CZ.
For now stay way away from the Winchester Safari Classic, except for the SS/synthetic model. The blue/walnut series have serious feeding problems. Yes, I've had several of them and got rid of all three...FAST! My SS/synthetic was a wonderful rifle, however. I sadly sold it to a first time safari hunter.
I am of the opinion, also, that a heavy caliber rifle should have at least two shots hiding within it...double rifle or magazine rifle...not a single shot. Big moose and larger bears are nothing to take lightly. :shock: :shock: We have some surley critters right here in North America. :twisted:
Well, there is a whole passal of opinions about the 375 H&H. I hope I haven't muddied up the water too much...