I have several NEFs with multiple barrels on almost all. I have .17HMR, .223, .243, 30-06, .35 Whelen, 45-70, .50cal, 28ga, 20ga, and 12ga.
I carry the 30-06 Handi, almost exclussively in the woods. I can hit a wolf at 600 yards regulerlly. I have a Shepard scope on it. This rifle takes a beating, I carry it on the handlebars of my motorcycle, fourwheeler, snowmachine, or lying on the dash of my track rig, or behind the seat of my pickup, or strapped to the windshield frame of my dune buggy. The Sheppard is my third scope on this rifle, a Tasco, and a Bushnell, did not hold up.